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Selected Publications by Medaffcon Oy

These articles, posters and study abstracts represent a subset of the biobank and other real world evidence -based studies conducted by Medaffcon.

Peer-reviewed articles

Hereditary Angioedema Type 1 and 2 in Finland: Incidence, Prevalence, and Preceding Diagnoses

Sandberg A, Lassenius M, Vihervaara V, Toppila I, Huila L. Acta Dermato-Venereologica (2024). DOI: 10.2340/actadv.v104.24176.

Use of Linked Nordic Registries for Population Studies in Hematologic Cancers:
The Case of Multiple Myeloma

Abildgaard N, Freilich J, Anttila P, Bent-Ennakhil N, Ma Y, Lassenius M, Ørstavik S, Toppila I, Waage A, Turesson I, Hansson M. Clinical Ep ). DOI: 10.2147/CLEP.S413587

Real-world treatment patterns of Finnish adult patients with atopic dermatitis: From topicals to systemic therapy

Kiiski V, Vikkula J, Ukkola-Vuoti L, Lassenius MI, Kopra J. JEADV Clinical Practice (2023). DOI: 10.1002/jvc2.247

Pediatric short bowel syndrome: real-world evidence on incidence and hospital resource use from a Finnish data lake

Puttonen M, Tuominen S, Ukkola-Vuoti L, Lassenius MI, Virtanen H, Merras-Salmio L, Pakarinen M. Journal of Pediatric Gastroenterology and Nutrition (2023). DOI: 10.1097/MPG.0000000000003894

The Burden of Genital Warts in Finland: Cross-Sectional Analysis of the Prevalence and Direct Medical Costs in 2018

Gylling A, Uusi-Rauva K, Toppila I, Hiltunen-Back E. Vaccines (2023). DOI: 10.3390/vaccines11071202

Type 2 Low Biomarker Stability and Exacerbations in Severe Uncontrolled Asthma

Viinanen A, Aakko J, Lassenius MI, Telg G, Nieminen K, Kaijala S, Lehtimäki L, Kankaanranta H. Biomolecules (2023). DOI: 10.3390/biom13071118

Smoking is a predictor of complications in all types of surgery: a machine learning-based big data study

Gräsbeck H, Reito A, Ekroos H, Aakko J, Hölsä O, Vasankari T. BJS Open (2023). DOI: 10.1093/bjsopen/zrad016

Burden of idiopathic inflammatory rheumatic diseases in occupational healthcare: increased absenteeism and healthcare resource utilization

Ukkola-Vuoti L, Karlsson A, Tuominen S, Lassenius MI, Aaltonen J, Ranta M, Kosunen M, Renlund M, Lehtonen A, Puolakka K. Scan J Work Environ Health (2023). DOI: 10.5271/sjweh.4095

Sydämen vajaatoiminnan ilmaantuvuus ja hoidon kustannukset Suomessa vuosina 2012-2019

Ukkola-Vuoti L, Toppila I, Säävuori N, Kirjavainen A, Ukkonen H, Pentikäinen M. Duodecim (2023) 2023;139(6):455-62.

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults

Kiiski V , Ukkola-Vuoti L, Vikkula J, Ranta M, Lassenius MI, Kopra J.
Acta Dermato-Venereologica (2023) Volume 103. DOI: 10.2340/actadv.v103.4447

The burden of chronic rhinosinusitis with nasal polyps and its relation to asthma in Finland

Toppila-Salmi S, Hällfors J, Aakko J, Mannerström B, Nieminen K, Telg G, Lehtimäki L. Clinical and Translational Allergy (2022) Volume 12, Issue 10. DOI: 10.1002/clt2.12200

Comorbidity characteristics of multiple myeloma patients diagnosed in Finland 2005-2016

Toppila I, Kysenius K, Miettinen T, Lassenius MI, Lievonen J, Anttila P. Annals of Hematology (2022) DOI: 10.1007/s00277-022-04959-9

Screening for potential undiagnosed Gaucher disease patients: Utilisation of the Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS) in conjunction with electronic health record data, tissue specimens, and small nucleotide polymorphism (SNP) genotype data available in Finnish biobanks

Pehrsson M, Heikkinen H, Wartivaara-Kautto U, Mäntylahti S, Bäckström P, Lassenius MI, Uusi-Rauva K, Carpén O, Elomaa K. Molecular Genetics and Metabolism Reports (2022) DOI: 10.1016/j.ymgmr.2022.100911

Cardiovascular outcome according to renal status in Finnish patients with type 2 diabetes

Hellman TA, Skare O-L, Lee C, Wagner U, Vikkula J, Hällfors J, Laatikainen O, Lassenius MI, Metsärinne K. Diabetes Epidemiology and Management (2022) DOI: 10.1016/j.deman.2022.100103

Retrospective, Registry-based, Cohort Investigation of Clinical Outcomes in Patients with Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma in Finland

Tuominen S, Ukkola-Vuoti L, Riihilä P, Knuutila JS, Kähäri VM, Lassenius M, Ranki T, Pousar K, Vassilev L, Vuoti S, Mattila K. Acta Derm Venereol (2022) DOI: 10.2340/actadv.v102.2073. PMID: 35356995.

Cardiovascular event rate and death in high-risk secondary prevention patient cohort in Finland: A registry study

Toppila I, Ukkola-Vuoti L, Perttilä J, Törnwall O, Sinisalo J, Hartikainen J, Lehto S. Clinical Cardiology (2022) DOI: 10.1002/clc.23814.

Real-world data on diffuse large B-cell lymphoma in 2010-2019: usability of large data sets of Finnish hospital data lakes

Tuominen S, Uusi-Rauva K, Blom T, Jyrkkiö S, Tuppurainen K, Alanne E. Future Oncology. 2022 Mar;18(9):1103-1114. doi: 10.2217/fon-2021-0806. Epub 2022 Feb 3. PMID: 35109670.

Real-World Clinical Outcomes in Biological Subgroups of Breast Cancer in the Hospital District of Southwest Finland

Teerenhovi H, Tuominen S, Nurmi-Rantala S, Hemmilä P, Ellonen A. The Oncologist (2021) DOI: 10.1002/onco.13813

The burden of hip and knee osteoarthritis in Finnish occupational healthcare

Summanen M, Ukkola-Vuoti L, Kurki S, Tuominen S, Madanat R. BMC Musculoskelet Disord (2021) DOI: 29;22(1):501.

Characteristics and survival trends in Finnish multiple myeloma patients – a nationwide real-world evidence study

Toppila I, Miettinen T, Lassenius MI, Lievonen J, Bauer M, Anttila P. Ann Hematol (2021). DOI: 10.1007/s00277-021-04481-4.

The Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS): Evaluation of a prototype in Finnish Gaucher disease patients and feasibility of screening retrospective electronic health record data for the recognition of potential undiagnosed patients in Finland

Savolainen MJ, Karlsson A, Rohkimainen S, Toppila I, Lassenius MI, Vaca Falconi C, Uusi-Rauva K ja Elomaa K. Molecular Genetics and Metabolism Reports (2021) DOI: 10.1016/j.ymgmr.2021.100725.

My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland

Sumelahti M-J, Sumanen M, Sumanen MS, Tuominen S, Vikkula J, Honkala SM, Rosqvist S ja Korolainen MA. The Journal of Headache and Pain (2020) DOI: 10.1186/s10194-020-01185-4.

Recurrent hospitalizations are associated with increased mortality across the ejection fraction range in heart failure

Huusko J, Tuominen S, Studer R, Corda S, Proudfoot C, Lassenius MI ja Ukkonen H. ESC Heart Failure (2020) DOI: 10.1002/ehf2.12792.

Real-world clinical diagnostics of heart failure patients with reduced or preserved ejection fraction

Huusko J, Purmonen T, Toppila I, Lassenius M ja Ukkonen H. ESC Heart Failure (2020) DOI: 10.1002/ehf2.12665.

Cardiovascular event rates increase after each recurrence and associate with poor statin adherence

Lassenius MI, Toppila I, Bergius S, Perttilä J, Airaksinen KEJ ja Pietilä M. European Journal of Preventive Cardiology (2020) DOI: 10.1177/2047487320904334.

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

Korolainen MA, Tuominen S, Kurki S, Lassenius MI, Toppila I, Purmonen T, Santaholma J ja Nissilä M. The Journal of Headache and Pain (2020) 21:8. DOI: 10.1186/s10194-020-1077-x.

Forced Vital Capacity (FVC) decline, mortality and healthcare resource utilization in idiopathic pulmonary fibrosis

Lassenius MI, Toppila I, Pöntynen N, Kasslin L, Kaunisto J, Kilpeläinen M ja Laitinen T. European Clinical Respiratory Journal (2019) 7:1, 1702618, DOI: 10.1080/20018525.2019.1702618.

The Burden Of Chronic Obstructive Pulmonary Disease (COPD) In Finland: Impact Of Disease Severity And Eosinophil Count On Healthcare Resource Utilization

Viinanen A, Lassenius MI, Toppila I, Karlsson A, Veijalainen L, Idänpään-Heikkilä JJ ja Laitinen T. International Journal of Chronic Obstructive Pulmonary Disease (2019) 14:2409-2421.

The burden of adult asthma in Finland: impact of disease severity and eosinophil count on health care resource utilization

Viinanen A, Lassenius M, Toppila I, Karlsson A, Veijalainen L, Idänpään-Heikkilä J ja Laitinen T. Journal of Asthma (2019). DOI: 10.1080/02770903.2019.1633664.

Heart failure in Finland: clinical characteristics, mortality, and healthcare resource use

Huusko J, Kurki S, Toppila I, Purmoen T, Lassenius M, Gullberg E, Bruce-Wirta S ja Ukkonen H. ESC Heart Failure (2019). DOI: 10.1002/ehf2.12443.

Burden of migraine in Finland: health care resource use, sick-leaves and comorbidities in occupational health care

Korolainen M, Kurki S, Lassenius M, Toppila I, Costa-Scharplatz M, Purmonen T ja Nissilä M. Journal of headache and pain (2019) 20:13. DOI: 10.1186/s10194-019-0964-5.

Type 2 diabetes and treatment intensification in primary care in Finland

Niskanen L, Hahl J, Haukka J, Leppä E, Miettinen T, Mushnikov V, Sipilä R, Tamminen N, Vattulainen P ja Korhonen P. Acta Diabetologica (2018) 55:1171-1179.

Health care resource utilization and characteristics of patients with eosinophilic asthma in secondary health care in Finland

Mäkelä MJ, Christensen HN, Karlsson A, Rastogi S ja Kettunen K. European Clinical Respiratory Journal (2018) 5(1):1458560.

Re-treatment with varenicline is a cost-effective aid for smoking cessation

Kautiainen K, Ekroos H, Puhakka M, Liira H, Laine J, Linden K, Hahl J. J Med Econ. 2017 Mar;20(3):246-252. DOI: 10.1080/13696998.2016.1249485.

Burden of illness in multiple sclerosis (DEFENSE) study: the costs and quality-of-life of Finnish patients with multiple sclerosis

Ruutiainen J, Viita A-M, Hahl J, Sundell J, Nissinen H. J Med Econ 2016;19(1):21-33. DOI: 10.3111/13696998.2015.1086362.

Posters or oral presentations at international congresses

The real-world dose differences of insulin glargine 300 U/ml in Finland

Koski L, Hahl J, Kaye S & Pousar K. ISPOR Europe, Nov 2019, Copenhagen, Denmark.

Migraine comorbidity and phenotypic disease networks in occupational health care

Korolainen M A, Kurki S, Tuominen S, Toppila I, Lassenius M I, Santaholma J, Purmonen T, Nissilä M. 19th Congress of the International Headache Society, Sep 7-8, 2019; Dublin, Ireland.

Study to determine predictive potential of an algorithm for earlier diagnosis of Gaucher disease: Retrospective biobank study utilizing real-world data available in Finland

Savolainen M, Karlsson A, Toppila I, Elomaa K, Panahloo Z, Wolf M. 15th Annual WORLD Symposium, Feb 4-8, 2019; Orlando, Florida, USA.

Health Registry Data Survey for Assessing Characteristics and Descriptive Epidemiology of Patients with Multiple Myeloma in Southwest Finland between 2004—May 2017

Salmi T, Saukkonen K, Wolf, M, Toppila I, Kurki S, Schoonen M, Putkonen M. ESH, 4th International Conference on multiple myeloma, Oct 5-7, 2018; Mandelieu, France.

Health care resource use, sick-leaves and comorbidities among migraine patients in occupational healthcare

Korolainen M A, Kurki S, Toppila I, Lassenius M, Purmonen T, Nissilä M. European Headache federation meeting, Sep 28-30, 2018; Florence, Italy.

Heart Failure in Finland – Evaluating the burden of disease and treatment patterns

Huusko J, Kurki S, Toppila I, Purmonen T, Lassenius M, Gullberg E, Bruce-Wirta S, Ukkonen H. European Society of Cardiology Congress, 2018; Munich, Germany.

Trend towards longer time to reimbursement in oncological medicines in Finland 2005-2015

Oinonen L, Renlund M, Pudas H, Ihalmo P, Hahl J. ISPOR, 2016.

The epidemiology of adult immune (idiopathic) thrombocytopenic purpura (ITP) in Finland: resource utilisation, related costs and hospital medication associated with the treatment of non-splenectomised adult ITP based on real world data from Auria biobank

Kosunen M, Kurki S, Snicker K, Wiik E. ISPOR, 2017.

Resource utilisation and related health care costs among patients with multiple myeloma with ≥ 2 prior lines of treatment in Finland: evaluation based on Finnish real world data from Auria biobank

Kosunen M, Kurki S, Snicker K, Wiik E. ISPOR, 2017.

Resource use, health care costs and burden of disease in patients with polycythemia vera in Finland: evaluation based on leukocyte counts using Finnish real world data from Auria biobank

Kosunen M, Kurki S, Snicker K, Wiik E. ISPOR, 2017.

Cost-effectiveness of Pasireotide long-acting in a treatment of acromegaly in Finland. Economic evaluation based on Finnish Auria biobank data on health care resource utilization

Hahl J, Kurki S, Miettinen T, Snicker K. ISPOR, 2015.


Lääkkeiden riskinjakosopimukset Suomen sairaaloissa – kyselytutkimus 2019

Honkanen H, Snicker K ja Ahlamaa J. Suomen Lääkärilehti 2019; 49:2872 – 2876.

Tutkimuksen uudet mahdollisuudet on huomioitava biopankkilaissa

Tuompo W, Hemmilä P, Ahlamaa J ja Wolf M. Finnish Medical Journal (2018) 37: 2006-2007.

Read summaries of our RWE studies

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