Selected Publications by Medaffcon Oy

These articles, posters and study abstracts represent a subset of the biobank and other real world evidence -based studies conducted by Medaffcon.


Peer-reviewed articles

Comorbidity characteristics of multiple myeloma patients diagnosed in Finland 2005-2016. Toppila I, Kysenius K, Miettinen T, Lassenius MI, Lievonen J, Anttila P. Annals of Hematology (2022) DOI: 10.1007/s00277-022-04959-9 

Screening for potential undiagnosed Gaucher disease patients: Utilisation of the Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS) in conjunction with electronic health record data, tissue specimens, and small nucleotide polymorphism (SNP) genotype data available in Finnish biobanks. Pehrsson M, Heikkinen H, Wartivaara-Kautto U, Mäntylahti S, Bäckström P, Lassenius MI, Uusi-Rauva K, Carpén O, Elomaa K. Molecular Genetics and Metabolism Reports (2022) DOI: 10.1016/j.ymgmr.2022.100911 

Cardiovascular outcome according to renal status in Finnish patients with type 2 diabetes. Hellman TA, Skare O-L, Lee C, Wagner U, Vikkula J, Hällfors J, Laatikainen O, Lassenius MI, Metsärinne K. Diabetes Epidemiology and Management (2022) DOI: 10.1016/j.deman.2022.100103 

Retrospective, Registry-based, Cohort Investigation of Clinical Outcomes in Patients with Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma in Finland, Tuominen S, Ukkola-Vuoti L, Riihilä P, Knuutila JS, Kähäri VM, Lassenius M, Ranki T, Pousar K, Vassilev L, Vuoti S, Mattila K. Acta Derm Venereol. 2022 Apr 8;102:adv00693. doi: 10.2340/actadv.v102.2073. PMID: 35356995.

Cardiovascular event rate and death in high-risk secondary prevention patient cohort in Finland: A registry study, Toppila I, Ukkola-Vuoti L, Perttilä J, Törnwall O, Sinisalo J, Hartikainen J, Lehto S. Clinical Cardiology. 2022 Apr;45(4):342-351. doi: 10.1002/clc.23814.

Real-world data on diffuse large B-cell lymphoma in 2010-2019: usability of large data sets of Finnish hospital data lakes, Tuominen S, Uusi-Rauva K, Blom T, Jyrkkiö S, Tuppurainen K, Alanne E. Future Oncology. 2022 Mar;18(9):1103-1114. doi: 10.2217/fon-2021-0806. Epub 2022 Feb 3. PMID: 35109670.

Real-World Clinical Outcomes in Biological Subgroups of Breast Cancer in the Hospital District of Southwest Finland, Teerenhovi H, Tuominen S, Nurmi-Rantala S, Hemmilä P, Ellonen A. The Oncologist (2021) DOI: 10.1002/onco.13813

The burden of hip and knee osteoarthritis in Finnish occupational healthcare, Summanen M, Ukkola-Vuoti L, Kurki S, Tuominen S, Madanat R. BMC Musculoskelet Disord (2021) DOI: 29;22(1):501. 

Characteristics and survival trends in Finnish multiple myeloma patients – a nationwide real-world evidence study, Toppila I, Miettinen T, Lassenius MI, Lievonen J, Bauer M, Anttila P. Ann Hematol (2021). DOI: 10.1007/s00277-021-04481-4.

The Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS): Evaluation of a prototype in Finnish Gaucher disease patients and feasibility of screening retrospective electronic health record data for the recognition of potential undiagnosed patients in Finland, Savolainen MJ, Karlsson A, Rohkimainen S, Toppila I, Lassenius MI, Vaca Falconi C, Uusi-Rauva K and Elomaa K. Molecular Genetics and Metabolism Reports (2021) DOI: 10.1016/j.ymgmr.2021.100725.

My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland, Sumelahti M-J, Sumanen M, Sumanen MS, Tuominen S, Vikkula J, Honkala SM, Rosqvist S and Korolainen MA. The Journal of Headache and Pain (2020) DOI: 10.1186/s10194-020-01185-4.

Recurrent hospitalizations are associated with increased mortality across the ejection fraction range in heart failure, Huusko J, Tuominen S, Studer R, Corda S, Proudfoot C, Lassenius MI ja Ukkonen H. ESC Heart Failure (2020) DOI: 10.1002/ehf2.12792.

Real-world clinical diagnostics of heart failure patients with reduced or preserved ejection fraction, Huusko J, Purmonen T, Toppila I, Lassenius M and Ukkonen H. ESC Heart Failure (2020) DOI: 10.1002/ehf2.12665.

Cardiovascular event rates increase after each recurrence and associate with poor statin adherence, Lassenius MI, Toppila I, Bergius S, Perttilä J, Airaksinen KEJ and Pietilä M. European Journal of Preventive Cardiology (2020) DOI: 10.1177/2047487320904334.

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare, Korolainen MA, Tuominen S, Kurki S, Lassenius MI, Toppila I, Purmonen T, Santaholma J and Nissilä M. The Journal of Headache and Pain (2020) 21:8. DOI: 10.1186/s10194-020-1077-x.

Forced Vital Capacity (FVC) decline, mortality and healthcare resource utilization in idiopathic pulmonary fibrosis, Lassenius MI, Toppila I, Pöntynen N, Kasslin L, Kaunisto J, Kilpeläinen M and Laitinen T. European Clinical Respiratory Journal (2019) 7:1, 1702618, DOI: 10.1080/20018525.2019.1702618.

The Burden Of Chronic Obstructive Pulmonary Disease (COPD) In Finland: Impact Of Disease Severity And Eosinophil Count On Healthcare Resource Utilization, Viinanen A, Lassenius MI, Toppila I, Karlsson A, Veijalainen L, Idänpään-Heikkilä JJ and Laitinen T. International Journal of Chronic Obstructive Pulmonary Disease (2019) 14:2409-2421.

The burden of adult asthma in Finland: impact of disease severity and eosinophil count on health care resource utilization, Viinanen A, Lassenius M, Toppila I, Karlsson A, Veijalainen L, Idänpään-Heikkilä J and Laitinen T. Journal of Asthma (2019). DOI: 10.1080/02770903.2019.1633664. 

Heart failure in Finland: clinical characteristics, mortality, and healthcare resource use, Huusko J, Kurki S, Toppila I, Purmoen T, Lassenius M, Gullberg E, Bruce-Wirta S and Ukkonen H. ESC Heart Failure (2019). DOI: 10.1002/ehf2.12443.

Burden of migraine in Finland: health care resource use, sick-leaves and comorbidities in occupational health care, Korolainen M, Kurki S, Lassenius M, Toppila I, Costa-Scharplatz M, Purmonen T and Nissilä M. Journal of headache and pain (2019) 20:13. DOI: 10.1186/s10194-019-0964-5.

Type 2 diabetes and treatment intensification in primary care in Finland, Niskanen L, Hahl J, Haukka J, Leppä E, Miettinen T, Mushnikov V, Sipilä R, Tamminen N, Vattulainen P and Korhonen P. Acta Diabetologica (2018) 55:1171-1179.

Health care resource utilization and characteristics of patients with eosinophilic asthma in secondary health care in Finland, Mäkelä MJ, Christensen HN, Karlsson A, Rastogi S and Kettunen K. European Clinical Respiratory Journal (2018) 5(1):1458560.

Re-treatment with varenicline is a cost-effective aid for smoking cessation. Kautiainen K, Ekroos H, Puhakka M, Liira H, Laine J, Linden K, Hahl J. J Med Econ. 2017 Mar;20(3):246-252. DOI: 10.1080/13696998.2016.1249485. 

Burden of illness in multiple sclerosis (DEFENSE) study: the costs and quality-of-life of Finnish patients with multiple sclerosis. Ruutiainen J, Viita A-M, Hahl J, Sundell J, Nissinen H. J Med Econ 2016;19(1):21-33. DOI: 10.3111/13696998.2015.1086362.


Posters or oral presentations at international congresses

The real-world dose differences of insulin glargine 300 U/ml in Finland. Koski L, Hahl J, Kaye S & Pousar K. ISPOR Europe, Nov 2019, Copenhagen, Denmark. 

Migraine comorbidity and phenotypic disease networks in occupational health care. Korolainen M A, Kurki S, Tuominen S, Toppila I, Lassenius M I, Santaholma J, Purmonen T, Nissilä M. 19th Congress of the International Headache Society, Sep 7-8, 2019; Dublin, Ireland

Study to determine predictive potential of an algorithm for earlier diagnosis of Gaucher disease: Retrospective biobank study utilizing real-world data available in Finland. Savolainen M, Karlsson A, Toppila I, Elomaa K, Panahloo Z, Wolf M. 15th Annual WORLD Symposium, Feb 4-8, 2019; Orlando, Florida, USA.

Health Registry Data Survey for Assessing Characteristics and Descriptive Epidemiology of Patients with Multiple Myeloma in Southwest Finland between 2004—May 2017. Salmi T, Saukkonen K, Wolf, M, Toppila I, Kurki S, Schoonen M, Putkonen M. ESH, 4th International Conference on multiple myeloma, Oct 5-7, 2018; Mandelieu, France.

Health care resource use, sick-leaves and comorbidities among migraine patients in occupational healthcare. Korolainen M A, Kurki S, Toppila I, Lassenius M, Purmonen T, Nissilä M. European Headache federation meeting, Sep 28-30, 2018; Florence, Italy.

Heart Failure in Finland – Evaluating the burden of disease and treatment patterns. Huusko J, Kurki S, Toppila I, Purmonen T, Lassenius M, Gullberg E, Bruce-Wirta S, Ukkonen H. European Society of Cardiology Congress, 2018; Munich, Germany.

Trend towards longer time to reimbursement in oncological medicines in Finland 2005-2015. Oinonen L, Renlund M, Pudas H, Ihalmo P, Hahl J. ISPOR, 2016. 

The epidemiology of adult immune (idiopathic) thrombocytopenic purpura (ITP) in Finland: resource utilisation, related costs and hospital medication associated with the treatment of non-splenectomised adult ITP based on real world data from Auria biobank. Kosunen M, Kurki S, Snicker K, Wiik E. ISPOR, 2017.

Resource utilisation and related health care costs among patients with multiple myeloma with ≥ 2 prior lines of treatment in Finland: evaluation based on Finnish real world data from Auria biobank. Kosunen M, Kurki S, Snicker K, Wiik E. ISPOR, 2017.

Resource use, health care costs and burden of disease in patients with polycythemia vera in Finland: evaluation based on leukocyte counts using Finnish real world data from Auria biobank. Kosunen M, Kurki S, Snicker K, Wiik E. ISPOR, 2017.

Cost-effectiveness of Pasireotide long-acting in a treatment of acromegaly in Finland. Economic evaluation based on Finnish Auria biobank data on health care resource utilization. Hahl J, Kurki S, Miettinen T, Snicker K. ISPOR, 2015.



Lääkkeiden riskinjakosopimukset Suomen sairaaloissa – kyselytutkimus 2019. Honkanen H, Snicker K and Ahlamaa J. Suomen Lääkärilehti 2019; 49:2872 – 2876.

Tutkimuksen uudet mahdollisuudet on huomioitava biopankkilaissa. Tuompo W, Hemmilä P, Ahlamaa J and Wolf M. Finnish Medical Journal (2018) 37: 2006-2007.


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